{
  "version": "nomogram-v1",
  "selected_clinical": [
    "age",
    "stage"
  ],
  "variables": [
    "risk",
    "age",
    "stage"
  ],
  "n_tcga_total": 1207,
  "n_tcga_complete": 1149,
  "deaths": 363,
  "by_cancer": {
    "colorectal": 598,
    "gastric": 377,
    "pancreatic": 174
  },
  "genomic_sha256": "b13b6876bb25dadf54801e10286ccd124c4d2d7a013e5c3d10be802846ebae67",
  "coefficient": {
    "risk": 0.9800746726837977,
    "age_per10": 0.33527757013971216,
    "stage_2": 0.18358105532492153,
    "stage_3": 0.5172672975507232,
    "stage_4": 1.2642638327501508
  },
  "centering": {
    "risk": -0.05455536610339427,
    "age_per10": 6.619181039489745,
    "stage_2": 0.42732811140121846,
    "stage_3": 0.3020017406440383,
    "stage_4": 0.11401218450826806
  },
  "seed": 20260906,
  "beta_interpretation": "shared effects, cancer-stratified baseline; raw genomic score + age/10 + categorical stage",
  "covariates_trained_on": "TCGA complete cases only; no GEO fitting",
  "points": {
    "points_per_log_hazard": 20.406608350803303,
    "minimum_uncentered_lp": -1.9343913076322565,
    "training_center": 2.5446010539242843,
    "displayed_total_max": 166.85060526291835,
    "formula": "S(t)=exp(-H0_cancer(t)*exp(minimum_uncentered_lp+total_points/points_per_log_hazard-training_center))"
  },
  "times_months": [
    12,
    36,
    60
  ],
  "baseline_hazard": {
    "colorectal": [
      0.1108482650799175,
      0.2556567954725295,
      0.5296692542998217
    ],
    "gastric": [
      0.15289655115731277,
      0.5115531306840468,
      0.7532189897664245
    ],
    "pancreatic": [
      0.13438696598984023,
      0.591916729971013,
      0.8352708112499112
    ]
  },
  "training_ranges": {
    "risk": [
      -2.5447202,
      1.9463086
    ],
    "age": [
      30.015058179329227,
      89.99863107460644
    ]
  },
  "source_sha256": "6eddf3326c7cd06ca639e3f94161bf7ad3e2e0425eea60e37cc93066ebb14bbd",
  "limitations": "Research only. Cancer-stratified baseline; shared covariate effects. External combined-model evaluation available for GSE17536, GSE39582 and GSE62254 only; no evaluable PAAD clinical validation. Absolute survival calibration is not established for clinical deployment."
}